·108·中华神经科杂志2024年2月第57卷第2期ChinJNeurol,February2024,Vol.57,No.2抗癫痫发作药物联合使用中国专家共识中华医学会神经病学分会中华医学会神经病学分会脑电图与癫痫学组通信作者：冯莉，中南大学湘雅医院神经内科，长沙410008，Email：fenglihx@163.com；周东，四川大学华西医院神经内科，成都610041，Email：zhoudong66@yahoo.de；朱遂强，华中科技大学同济医学院附属同济医院神经内科，武汉430030，Email：zhusuiqiang@163.com【摘要】癫痫是中枢神经系统常见的慢性疾病之一，给予抗癫痫发作药物（ASMs）是其最重要的治疗手段，初始单药未达到癫痫缓解的治疗目标时，可选择更换单药或联合添加治疗。中国目前有超过20种上市的ASMs，对于何时启动联合治疗、联合用药的方案、多药治疗的注意事项等问题常给临床决策带来困扰。为此，中华医学会神经病学分会脑电图与癫痫学组组织相关专家，讨论并撰写本共识，旨在为我国癫痫疾病的药物联合治疗提供更加实用、规范的治疗方案及用药指导。【关键词】癫痫；抗癫痫发作药物；联合用药；共识Chineseconsensusfortheanti‑seizuremedicationspolytherapyChineseSocietyofNeurology,ChineseSocietyofElectroencephalographyandEpilepsyCorrespondingauthors:FengLi,DepartmentofNeurology,XiangyaHospitalofCentralSouthUniversity,Changsha410008,China,Email:fenglihx@163.com;ZhouDong,DepartmentofNeurology,WestChinaHospitalofSichuanUniversity,Chengdu610041,China,Email:zhoudong66@yahoo.de;ZhuSuiqiang,DepartmentofNeurology,TongjiHospital,TongjiMedicalCollegeofHuazhongUniversityofScienceandTechnology,Wuhan430030,China,Email:zhusuiqiang@163.com【Abstract】Epilepsyisoneofthecommonchronicdiseasesofthecentralnervoussystem,andthetherapyofanti‑seizuremedications(ASMs)isthemostimportanttherapymethodforepilepsy.Ifthetreatmentgoalofseizure‑freeisnotreachedaftertheinitialmonotherapy,anotherASMsshouldbeselectedassubstitutionorcombinationtherapy.Atpresent,therearemorethan20kindsofASMslicensedforuseinChina.Aseriesofproblems,suchaswhentostarttheASMspolytherapy,thechoiceofpolytherapyschedules,andtheprecautionsforpolytherapy,oftencauseproblemsforclinicianstomakedecisions.Therefore,expertsfromtheChineseSocietyofElectroencephalog...
